Today I was going through my drive with DaisyDisk to see what was taking up large amounts of space on my relatively small SDD hard drive. One culprit was the folder: /Users/Jonathan/Library/Application Support/Adobe/Common/Media Cache Files
Some of the files in here were close to 2 gb in size. Adobe has the following to say about these files:
I have put in bold blue the parts relevant to cleaning up these files. In my case using the Clean button only removed some of the files. Some very large files remained. So I deleted those manually. The key point is that it is safe to do so.